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Manufacturing Investments: Cell and Gene Therapies

CBM combines process development, plasmid DNA, viral vectors, cell banking, cell processing, and support testing capabilities.

The Center for Breakthrough Medicines, a new CDMO and specialty investment company with a planned investment of $1.1-billion for a cell- and gene-therapy manufacturing facility in King of Prussia, Pennsylvania. The CDMO is occupying over 40% of The Discovery Labs’s 1.6-million-square-foot biotech, healthcare and life-sciences campus in King of Prussia. The new CDMO will provide preclinical through commercial manufacturing of cell and gene therapies and component raw materials as well as process development, plasmid DNA, viral vectors, cell banking, cell processing, and support testing capabilities. Renovations are underway to construct a total of 86 plasmid, viral vector production, universal cell processing, cGMP testing, process development and cell-banking suites. As of the company’s announcement in January 2020, the company was in the process of reserving capacity for late 2020…

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April 22, 2020

Real Estate Mogul Brian O’Neill’s Big Health-Care Bet


Brian O’Neill doesn’t bet small. Nearly every venture the Philadelphia real estate magnate has pursued over his 30-year career was once deemed too big, too expensive, or, in some cases, just too outrageous to get done. More than a few of those projects have caved under the weight of O’Neill’s blind ambition. But he still embraces big vision.

Unconventional habits, like reading five newspapers before 5 a.m. every morning and doggedly recruiting some of the world’s leading talent — O’Neill once pursued a health-care administrator for four years until she finally joined his team — have sharpened his knack for making investments in the right places at the right time. As O’Neill explains it, it’s about envisioning an enormous goal and working backwards, filling in the details as he inches closer to a project’s completion…

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April 11, 2020

The Center for Breakthrough Medicines’ Cell and Gene Therapy Manufacturing Facility, King of Prussia


The Center for Breakthrough Medicines, a contract development and manufacturing organisation (CDMO), is developing the world’s largest and most advanced single-point facility for cell and gene therapy manufacturing in King of Prussia, Pennsylvania, US…

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April 10, 2020