Choosing the Right Expression System for Complex Modalities

Feliza Mirasol, BioPharm International.

The choice of expression system requires wise consideration of product complexities.

Despite the advent of advanced technologies to meet the needs of novel biopharmaceuticals in development, the manufacturing processes for these molecules remains complex and challenging. New issues that are emerging in the upstream processing stage give rise to further considerations in terms of scalability, cost, and process robustness. A closer look at up-and-coming categories of biomolecules in the development pipeline can give further insight into how the industry can best address new and emerging hurdles.

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