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New Technical White Paper: Manufacture the Highest Quality Precision Plasmids™ with a Reliable Platform Process

February 9, 2023

The Growing Demand for Plasmids

Since the first pharmaceutical application of plasmids (their introduction into bacteria to enable the production of therapeutic proteins) was achieved in the 1970s, plasmids have become critical starting materials for many advanced drug products. They are used to transfect mammalian cells to manufacture complex recombinant proteins, antibodies, and other biologic drug substances. With the increasing investment in advanced therapies such as viral vectors, cell-mediated, and nucleic acid-based modalities, plasmid manufacturing has become a major bottleneck to deliver these therapies. Plasmid transfection into mammalian cells is the predominant production method for viral vectors. Plasmids also serve as the template for mRNA manufacturing and have potential applications as vaccines and other therapeutics….

Download the full technical white paper here.

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