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What is Viral Vector Manufacturing

January 17, 2021

Viral vector manufacturing is the process of producing viral vectors, which are viruses that have been modified to deliver specific genetic material to a cell. These modified viruses are used in a variety of applications, including gene therapy, vaccination, and as tools in research.

The process of viral vector manufacturing involves several steps, including:

• Vector Design: First, the genetic material that the vector will deliver is selected and inserted into the viral genome.

• The viral genome is modified so that it does not cause disease, but can still infect target cells and deliver the genetic material.

• Vector Production: The viral vector is then produced in large quantities in specialized cells, typically by infecting them with the modified virus. This step can be done using various techniques, including transient transfection or stable cell line generation.

• Purification: Once the vector is produced, it must be purified to remove any impurities or contaminants. This is typically done using a series of filtration and chromatography steps.

• Quality Control: Finally, the purified vector is tested for potency, safety, and purity to ensure that it meets quality control standards. This step involves rigorous testing to identify any potential safety concerns or impurities that could affect the effectiveness of the vector.

• Viral vector manufacturing is a complex process that requires specialized expertise and facilities to ensure that the resulting vectors are safe and effective for their intended use.

Learn more about Center for Breakthrough Medicines viral vector capabilities:

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