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The CBM Difference

Center for Breakthrough Medicines (CBM) is an advanced therapy focused CDMO dedicated to delivering life-changing treatments to the patients that need them.

Our team working at one of the more than 20 Viral Vector production suites

Located in the birthplace of cell & gene therapy, with know-how from its pioneers

CBM is in a unique location at the birthplace of cell and gene therapy, in one of the largest clusters of clinical and commercial advanced therapies experience in the United States. The most influential organizations and greatest pioneering minds in the industry are here. There is no greater centralization of knowledge, and our own team contains members of the small universe of people to have commercialized advanced therapies.

Close to Philadelphia, our campus is the largest fully integrated single-site development and manufacturing facility in the advanced therapies market. We have more than 20 suites for viral vector production and over 20 dedicated to cell therapy, with unlimited flexibility for on-site customization and expansion tailored to client needs.

CBM also has market-leading partnerships with world-renowned academic institutions and leading specialists, including our collaboration with the lab that pioneered the first gene therapy.

“Innovation thrives in Cellicon Valley with world-class research institutions, abundant life science talent, incredible transportation infrastructure including cold chain, 12 million sq ft of lab space, and world-class hospital systems.”
Audrey Greenberg, Co-founder, CBM
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Co-founder, Audrey Greenberg at the CMB campus near Philadelphia, which houses over 20 cell therapy manufacturing suites

Flexible & Transparent Partnership

CBM believes a truly collaborative partnership is imperative to a program’s success. We understand that a partnership is a two-way relationship and refer to clients who are onsite at CBM as Partner in Plant

While we have a dedicated area with private meeting rooms on site for our Partners, we welcome our Partners - with proper training - to be onsite in their suite during production.  We also offer full livestreaming of the process to allow clients to witness and support critical operations either remotely or while onsite with limited disruption to the process. 

Our campus near Philadelphia houses our Viral Vector Manufacturing and Cell Therapy Manufacturing facilities.

Large Fully Integrated Facility

Our single-site facility 20 miles outside Philadelphia is another key differentiator for CBM. It is the industry’s largest fully integrated campus, housing the only end-to-end advanced therapies platform that combines full lifecycle viral vector, cell therapy and plasmid DNA production under one roof with supporting analytical development and testing. With facility space dedicated to our Partner-in-Plant philosophy, we have a fully transparent working relationship with our customers, enabling dynamic collaboration as the program progresses.

The 700,000 square foot facility was purpose built with state-of-the-art equipment and a platform of strong foundational processes and systems. Beyond custom engineered buildings and areas that segregate but integrate our portfolio of services, the campus offers flexible, customizable suites and significant strategic business and operational expansion opportunities for our clients who are growing their cell and gene therapy programs.

An employee from our Plasmid DNA production

Differentiated from other CDMOs

Client-Centric Flexible Capacity

World-class engineering and abundant space at our site enable turnkey expansion to meet your needs, with modular design and BLA-ready suites offering high throughput and maximized yields.

Single Site Facility

Our comprehensive cell & gene therapy capabilities are fully integrated on a single campus for seamless transition between development, manufacturing, and testing.

Expert Team

Our leaders hail from top-tier cell & gene therapy CDMOs and innovator companies, bringing rare first-hand experience of taking advanced therapies all the way to commercialization.

Transparent, Committed CDMO

Our transparent approach includes a Partner-in-Plant philosophy that optimizes your control and visibility of programs, and we are willing to put skin in the game with flexible terms and milestone-based agreements.

Seamless Analytical Capabilities

Cutting-edge analytical infrastructure and techniques are integrated adjacent to production, so your program gets the critical answers around safety, efficacy, and potency.

World-Class GMP Manufacturing

Our clinical and commercial GMP manufacturing offers end-to-end capabilities from process development to drug substance manufacturing and drug product filling, supported by full testing capabilities.
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